Table 1

Enrichment P-values for overrepresented regulatory path motifs. Enrichment P-values for overrepresented regulatory path motifs in deletion and overexpression data with the two randomization methods described in the Methods. The complete tables for all 39 paths can be found in Tables S4 and S5 in Additional File 1).

Regulatory path

Perturbational data randomization

Physical network randomization

Deletion data

TRI

7.3 × 10^-38

4.08 × 10^-34

TRI-TRI

6.95 × 10^-7

1.41 × 10^-4

TRI-PPI

5.66 × 10^-3

1.77 × 10^-2

PPI-TRI

1.96 × 10^-17

1.87 × 10^-10

PPI-PhI-TRI

8.10 × 10^-3

1.4 × 10^-3

PPI-TRI-TRI

2.01 × 10^-3

2.1 × 10^-3

Overexpression data

TRI

1.1 × 10^-13

2.46 × 10^-9

TRI-TRI

2.74 × 10^-7

2.02 × 10^-2

PPI-TRI

1.21 × 10^-7

7.54 × 10^-4

PPI-PhI-TRI

2.59 × 10^-5

8.20 × 10^-4

PPI-TRI-TRI

1.58 × 10^-7

3.27 × 10^-4

TRI-PhI-TRI

6.17 × 10^-8

6.32 × 10^-2

TRI-PPI-TRI

1.96 × 10^-4

6.12 × 10^-2

Joshi et al. Genome Biology 2010 11:R32   doi:10.1186/gb-2010-11-3-r32