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Mapping the complexity of transcription control in higher eukaryotes

Pavel Tomancak1 and Uwe Ohler234*

Author Affiliations

1 Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany

2 Institute for Genome Sciences & Policy, Duke University Medical Center, 101 Science Drive, Durham, NC 27708, USA

3 Department of Biostatistics and Bioinformatics, Duke University School of Medicine, 2301 Erwin Road, Durham, NC 27710, USA

4 Department of Computer Science, Duke University, LSRC Building D101, 450 Research Drive, Durham, NC 27708, USA

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Genome Biology 2010, 11:115  doi:10.1186/gb-2010-11-4-115

Published: 30 April 2010

Abstract

Recent genomic analyses suggest the importance of combinatorial regulation by broadly expressed transcription factors rather than expression domains characterized by highly specific factors.