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Review

Are homologies in vertebrate sex determination due to shared ancestry or to limited options?

Jennifer A Marshall Graves1* and Catherine L Peichel2

Author Affiliations

1 Research School of Biology, the Australian National University, Canberra, ACT 0200, Australia

2 Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA

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Genome Biology 2010, 11:205  doi:10.1186/gb-2010-11-4-205

Published: 30 April 2010

Abstract

The same candidate genes and the same autosomes are repeatedly used as sex chromosomes in vertebrates. Are these systems identical by descent, or are some genes or chromosomes intrinsically better at triggering the first steps of sex determination?