Table 1

Genetic loci involved in sex determination in vertebrates

Locus

Gene name

Type of protein product

SRY

Sex-determining region on the Y chromosome

HMG-box transcription factor

SOX3

SRY-like, HMG-box-containing gene family, member 3

HMG-box transcription factor

SOX9

SRY-like, HMG-box-containing gene family, member 9

HMG-box transcription factor

SF1

Steroidogenic factor 1

Transcription factor of the steroid receptor family

FGF9

Fibroblast growth factor 9.

Secreted intercellular signal

WNT4

Wingless-type MMTV integration site family, member 4

Secreted intercellular signal

RSPO1

R-spondin-1

Secreted intercellular signal

DMRT1

Doublesex and mab-3 related transcription factor 1

Transcription factor

DMY

DMRT1 homolog on the Y in Oryzias latipes

Transcription factor

DM-W

DMRT1 homolog on the W in Xenopus laevis

Transcription factor

DGCR8

DiGeorge syndrome critical region, gene 8

microRNA biogenesis protein

RBMY

RNA-binding motif protein, Y-linked

RNA binding protein

TSPY

Testis-specific protein, Y-linked

Growth promoting factor and candidate gonadoblastoma gene.

Marshall Graves and Peichel Genome Biology 2010 11:205   doi:10.1186/gb-2010-11-4-205