Overview of the IMAGE process. Step one, Illumina reads are aligned against the initial assembly. Step two, Illumina reads that align to contig ends, along with their non-aligning mate adjacent to gaps, are assembled into new contigs, which are subsequently mapped back to the initial assembly. Step three, Illumina reads are aligned against the updated assembly and the whole process is repeated iteratively until the gap is closed.
Tsai et al. Genome Biology 2010 11:R41 doi:10.1186/gb-2010-11-4-r41