Flux balance analysis accounting for metabolite dilution
1 The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel
2 The Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
3 Computer Science Department, Technion - Israel Institute of Technology, Haifa 32000, Israel
Genome Biology 2010, 11:R43 doi:10.1186/gb-2010-11-4-r43Published: 16 April 2010
Flux balance analysis is a common method for predicting steady-state flux distributions within metabolic networks, accounting for the growth demand for the synthesis of a predefined set of essential biomass precursors. Ignoring the growth demand for the synthesis of intermediate metabolites required for balancing their dilution leads flux balance analysis to false predictions in some cases. Here, we present metabolite dilution flux balance analysis, which addresses this problem, resulting in improved metabolic phenotype predictions.