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Open Access Method

Flux balance analysis accounting for metabolite dilution

Tomer Benyamini1*, Ori Folger1, Eytan Ruppin12 and Tomer Shlomi3*

Author affiliations

1 The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel

2 The Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel

3 Computer Science Department, Technion - Israel Institute of Technology, Haifa 32000, Israel

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Citation and License

Genome Biology 2010, 11:R43  doi:10.1186/gb-2010-11-4-r43

Published: 16 April 2010

Abstract

Flux balance analysis is a common method for predicting steady-state flux distributions within metabolic networks, accounting for the growth demand for the synthesis of a predefined set of essential biomass precursors. Ignoring the growth demand for the synthesis of intermediate metabolites required for balancing their dilution leads flux balance analysis to false predictions in some cases. Here, we present metabolite dilution flux balance analysis, which addresses this problem, resulting in improved metabolic phenotype predictions.