Frequency histograms of signal intensities for experimental and control tiles. (a) Digested DNA (green, labeled with Cy3) and non-digested DNA (red, Cy5) binding to restriction cut site centered tiles. (b) Cy5 signal intensities for negative control tiles (blue, randomly generated tiles that did not match anywhere in the genome according to BLASTN) and positive control tiles (magenta, matching multi-copy ribosomal DNA).
Pespeni et al. Genome Biology 2010 11:R44 doi:10.1186/gb-2010-11-4-r44