Figure 2.

Higher-order interactions. As the left-hand side of the diagram shows, multiple perturbations within a single species (for example, double mutants subjected to multiple conditions or stresses) are now possible and are delving into previously unexplored interactome space. The right-hand side of the diagram symbolizes how in the future, simultaneous studies such as these on several different species interacting with each other will be possible.

Fischbach and Krogan Genome Biology 2010 11:208   doi:10.1186/gb-2010-11-5-208
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