Remodeling of individual nucleosomes. (a) Read density and calculated nucleosome scores for wild-type (WT) and three mutant strains at three genes (MSM1, which has similar nucleosome patterns for all strains, and ATP23 and PET123, which have different nucleosome patterns at Δisw1), including examples of the three classes of changes that we defined: shift, loss/gain and occupancy (Occ.). Estimated nucleosome center positions are indicated as black (wild-type) or red (Δisw1) circles with nucleosome numbering. (b) Number of changes identified over all genes examined. Horizontal lines indicate the number of changes observed among biological repeats. (c) Number of changes that are found in both S. cerevisiae and S. paradoxus.
Tirosh et al. Genome Biology 2010 11:R49 doi:10.1186/gb-2010-11-5-r49