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Dramatic changes in transcription factor binding over evolutionary time

Matthew T Weirauch1 and Timothy R Hughes12*

Author Affiliations

1 Banting and Best Department of Medical Research and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada

2 Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada

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Genome Biology 2010, 11:122  doi:10.1186/gb-2010-11-6-122

Published: 1 June 2010

Abstract

A recent study reveals a surprisingly high degree of change in the occupancy patterns of two transcription factors in the livers of five vertebrates.