Escape from X inactivation in mice and humans
1 Department of Pathology, University of Washington, Seattle, Washington 98195, USA
2 Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Genome Biology 2010, 11:213 doi:10.1186/gb-2010-11-6-213Published: 24 June 2010
A subset of X-linked genes escapes silencing by X inactivation and is expressed from both X chromosomes in mammalian females. Species-specific differences in the identity of these genes have recently been discovered, suggesting a role in the evolution of sex differences. Chromatin analyses have aimed to discover how genes remain expressed within a repressive environment.