The basal expression level and dosage sensitivity of HSA21 genes in mES cells. The effective genes are highlighted in blue, and the silent genes in red. (a) Selected HSA21 genes sorted according to their average expression level in mES cells, from the most (gene rank = 1) to the least expressed. (b) Selected HSA21 genes sorted according to the total length of the 'disordered' region of the encoded protein (measured with the GlobPlot tool).
De Cegli et al. Genome Biology 2010 11:R64 doi:10.1186/gb-2010-11-6-r64