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How do proteins gain new domains?

Joseph A Marsh and Sarah A Teichmann*

Author Affiliations

MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

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Genome Biology 2010, 11:126  doi:10.1186/gb-2010-11-7-126

Published: 15 July 2010

Abstract

A study of the contributions of different mechanisms of domain gain in animal proteins suggests that gene fusion is likely to be most frequent.