Figure 2.

Hypothetical model of a multidomain protein gaining an intrinsically disordered region via a carboxy-terminal exon extension. This protein has three folded domains (based on Protein Data Bank entry 1BIB), colored yellow, blue and red, and a 40-residue disordered extension at its carboxyl terminus, colored green. The folded domains are shown as a surface representation, and the disordered region is shown as an ensemble model with multiple distinct structures representing its substantial conformational heterogeneity.