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Highly Accessed Review

Nuclear transcription factors in mammalian mitochondria

Sarah Leigh-Brown12, José Antonio Enriquez34 and Duncan T Odom12*

Author Affiliations

1 Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK

2 University of Cambridge, Department of Oncology, Hutchison/MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK

3 Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernandez Almagro 3, 28029 Madrid, Spain

4 Departamento de Bioquímica, Universidad de Zaragoza, Pedro Cerbuna 9, 50009 Zaragoza, Spain

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Genome Biology 2010, 11:215  doi:10.1186/gb-2010-11-7-215

Published: 29 July 2010

Abstract

Nuclear transcription factors have been detected in mammalian mitochondria and may directly regulate mitochondrial gene expression. Emerging genomics techniques may overcome outstanding challenges in this field.