Table 1 |
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Attributes of each of the tiers |
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Tier 1 |
Tier 2 |
Tier 3 |
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Goal |
Explore and analyze new areas of biology |
Organize an appropriate area of biology |
Aggregate across all biology, provide information infrastructures |
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Main style of funding |
Response-mode and strategic grants for specific key datasets |
Strategic grants for an area of biology, with portions of response-mode grants for specific datasets |
Infrastructure funds, coupled to portions of strategic grants for specific biological areas |
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Time horizon of group |
Grant-driven, 3-5 years |
Strategic grant driven, 5-10 years |
Infrastructure driven, 10-20 years |
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Examples |
Many response-mode laboratories in universities and academic institutions |
Bioinformatics resource centers (BRCs), model organism databases |
EBI (Ensembl, Ensembl Genomes), NCBI (RefSeq) |
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Parkhill et al. Genome Biology 2010 11:402 doi:10.1186/gb-2010-11-7-402 |
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