Frequency of gains and losses in the metastatic precursor clones of 14 patients with metastatic prostate cancer. Fourteen patients with various metastatic samples taken from different anatomic sites were analyzed with the TuMult algorithm to generate the lineage of the metastases and to reconstruct the copy number profile of the common precursor of all metastases in each patient. The frequency of gains (in red) and losses (in green) in the genome were calculated for these 14 metastatic precursor clones.
Letouzé et al. Genome Biology 2010 11:R76 doi:10.1186/gb-2010-11-7-r76