Figure 7.

Metastases spreading in a patient with prostate cancer. Five metastases were removed from patient 21 (data from Liu et al. [19]), including three liver metastases (21-2a, 21-2b and 21-2c), one adrenal metastasis (21-3) and one bone metastasis (21-6). (a) Tumor progression tree reconstructed with the TuMult algorithm. The three liver metastases have a longer clonal relationship than the other metastases, all being derived from common precursor 3. (b) Copy number profiles of chromosome 2 in the five metastases. Four common aberrations, delimited by dashed lines, occurred in the common precursor of all the samples. The seven circled aberrations are specific to the three liver metastases, showing these tumors diverged later in the tumor progression tree. These aberrations appeared in common precursor 3, from which the liver metastases are derived.