Additional file 2.
Tumor progression trees of metastatic prostate cancers with several metastases from the same anatomic site or type of organ. (a) Tumor progression trees of three patients with several metastases from the same anatomic site (liver). Liver samples were always more closely related to each other than to metastases from the other organs. In each tree, the liver samples are derived from a single common precursor, with a substantial number of events not encountered in the other samples. (b) Tumor progression trees of six patients with several metastases from the same type of organ but at different anatomic sites (lymph node and/or bone metastases). The tumors from the same type of organ are associated in P24, P28 and P30, but not in P17, P32 and P33.
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Letouzé et al. Genome Biology 2010 11:R76 doi:10.1186/gb-2010-11-7-r76