Additional file 5.

Two scenarios lead to an unbalanced chromosome in the common precursor. (a) Left: the two tumors independently acquire two different aberrations with a breakpoint in common. Right: the 'up' breakpoint between segments B and C in the common precursor is lost in tumor 2 due to the loss of the neighboring segment C. (b) In both cases, only one breakpoint remains common to both samples, resulting in an unbalanced chromosome for their common precursor.

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LetouzĂ© et al. Genome Biology 2010 11:R76   doi:10.1186/gb-2010-11-7-r76