Figure 3.

Cluster structure and dynamics. (a) Each of the 17 clusters appears as a bubble containing up to three colored nodes whose sizes represent the number of genes contributed by each species. Edge thickness denotes the percent of gene orthology shared within or between clusters, measured using the size of the intersection divided by the size of the union of the sample sets. Only significant edges (P < 0.01) are shown. Several clusters show conserved orthology but not dynamics (for example, cluster 10 Sc, Cg with cluster 15 Kl). Note that clusters were ordered to minimize orthology edge crossings. (b) Expression dynamics of the 17 soft clusters over time following fluconazole exposure. Separate plots for each species can be found in Additional file 1. The width of each band corresponds to ± one standard deviation about the mean. A selection of enriched GO terms are shown for different clusters; see Figure S11 in Additional file 1 for full GO enrichment results. The number of genes for each species in each cluster is also shown.