Divergence in transporter usage. Cross-species expression profiles of (a) ATP-binding cassette (ABC) and (b) major facilitator superfamily (MFS) transporters are shown. Grey expression values denote a gene for which the species lacks an ortholog. (c) Change in cell density with addition of exogenous ergosterol at the fluconazole 50% inhibitory concentration across different mutant backgrounds. Sc.bpt1Δ is a gene knockout unrelated to fluconazole response and is included as a control. Error bars indicate one standard deviation. (d) Model for differential usage of transporters among Sc, Cg, and Kl.
Kuo et al. Genome Biology 2010 11:R77 doi:10.1186/gb-2010-11-7-r77