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Open Access Research

Paternally biased X inactivation in mouse neonatal brain

Xu Wang12, Paul D Soloway3 and Andrew G Clark12*

Author Affiliations

1 Deptartment of Molecular Biology and Genetics, Cornell University, 227 Biotechnology Building, Ithaca, NY 14853, USA

2 Cornell Center for Comparative and Population Genomics, 130 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA

3 Division of Nutritional Sciences, College of Agriculture and Life Sciences, 211 Weill Hall, Cornell University, Ithaca, NY 14853, USA

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Genome Biology 2010, 11:R79  doi:10.1186/gb-2010-11-7-r79

Published: 27 July 2010

Additional files

Additional file 1:

Figure S1. Distribution of imprinting status of 5,000 genes covered by the RNA-seq study.

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Additional file 2:

Table S1. Kolmogorov-Smirnov tests of p1-p2 distribution of different chromosome pairs.

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Additional file 3:

Table S2. Gene selection for pyrosequencing.

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Additional file 4:

Table S3. Least squares means (LS means) of fixed effect genes and mother.

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Additional file 5:

Figure S2. Allele-specific expression ratio of 20 genes in P2 brains of 11 female mice from each of the two reciprocal crosses between B6 and CAST strains.

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Additional file 6:

Table S4. Nonparametric analysis of variance table of the PWD × AKR data of X-linked genes subject to X inactivation.

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Additional file 7:

Table S5. Variance component analysis.

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Additional file 8:

Table S6. Analysis of variance table of the pooled data (PWD × AKR and B6 × CAST crosses) of X-linked genes subject to X inactivation. Type III sums of squares are reported.

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Additional file 9:

Figure S3. Estimation of the number of brain-forming cells at the time of X inactivation in mouse.

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Additional file 10:

Data S1. Raw pyrosequencing data summary table.

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Additional file 11:

Data S2. Raw pyrosequencing data file 1.

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Additional file 12:

Data S3. Raw pyrosequencing data file 2.

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