Dosage compensation and the global re-balancing of aneuploid genomes
Adolf-Butenandt-Institute and Centre for Integrated Protein Science (CiPSM), Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany
Genome Biology 2010, 11:216 doi:10.1186/gb-2010-11-8-216Published: 26 August 2010
Diploid genomes are exquisitely balanced systems of gene expression. The dosage-compensation systems that evolved along with monosomic sex chromosomes exemplify the intricacies of compensating for differences in gene copy number by transcriptional regulation.