Figure 1.

Features used in the mirSVR model. mirSVR uses features derived from the miRanda-predicted miRNA::site duplex, the local context of the candidate site, and the global context of the site in the 3' UTR. Duplex features include a bit representation of base-pairing at the seed region and the extent of 3' binding. Local features include AU composition flanking the target site and secondary structure accessibility score. Global features include length of UTR, relative position of target site from UTR ends, and conservation level of the block containing the target site.