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This article is part of the supplement: Beyond the Genome: The true gene count, human evolution and disease genomics

Invited speaker presentation

Between a chicken and a grape: estimating the number of human genes

Mihaela Pertea1 and Steven L Salzberg2*

  • * Corresponding author: Steven L Salzberg

Author Affiliations

1 Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA

2 Department of Computer Science, University of Maryland, College Park, MD 20742, USA

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Genome Biology 2010, 11(Suppl 1):I1  doi:10.1186/gb-2010-11-s1-i1

The electronic version of this article is the complete one and can be found online at: http://genomebiology.com/2010/11/S1/I1


Published:11 October 2010

© 2010 Salzberg and Pertea; licensee BioMed Central Ltd.

Invited speaker presentation

Ever since the discovery of the genetic code, scientists have been trying to catalog all the genes in the human genome. Over the years, the best estimate of the number of human genes has grown steadily smaller, but we still do not have an accurate count. Many expected this question to be resolved with the publication of the human genome sequence in 2001, but estimates have continued to fluctuate since then, moving both up and down. Comparisons with other species show that nothing about the human gene count is exceptional, and it is not particularly different from other mammalian species. In this talk, I will review the history of efforts to establish the human gene count and explain the evidence behind the current best estimate of 22,333 genes.