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This article is part of the supplement: Beyond the Genome: The true gene count, human evolution and disease genomics

Invited speaker presentation

Transcriptomics in a high throughput world

Chad Nusbaum

  • Correspondence: Chad Nusbaum

Author Affiliations

Genome Sequencing and Analysis Program, Broad Institute, Cambridge MA 02141, USA

Genome Biology 2010, 11(Suppl 1):I12  doi:10.1186/gb-2010-11-s1-i12

The electronic version of this article is the complete one and can be found online at: http://genomebiology.com/2010/11/S1/I12


Published:11 October 2010

© 2010 Nusbaum; licensee BioMed Central Ltd.

Invited speaker presentation

Sequencing-based approaches are transforming our ability to investigate, interpret and define transcriptomes, which comprise the expressed elements in genomes. This is driven by innovations in all steps in the process, including sample preparation, cDNA library construction, increases in sequencing data yield and development of new computational approaches. I will describe the state of the art in the field as well as new approaches and results from current work in transcriptome analysis at the Broad Institute.