Table 2

Host susceptibility genes identified by GWAS studies

Pathogen

Phenotype

Gene

N cases/controls

Effect size

P-value

References


Dengue virus

Severe dengue

MICB

3, 742/4, 952

1.34

4.41 × 10-11

[20]

Severe dengue

PLCE1

3, 742/4, 952

0.80

3.08 × 10-10

[20]

N. meningitidisa

Meningococcal disease

CFH

1, 443/6, 079

0.64

2.2 × 10-11

[7]

P. falciparuma

Severe malaria

ABO

3, 906/5, 489

1.20

2.0 × 10-7

[49,62]

Severe malaria

HBB

2, 045/3, 758

0.63

3.7 × 10-11

[62]

M. leprae

Leprosy

NOD2

3, 960/7, 180

1.59

3.77 × 10-40

[5]

RIPK2

3, 960/7, 180

0.76

1.38 × 10-16

[5]

HLA-DR

3, 960/7, 180

0.67

5.35 × 10-27

[5]

TNFSF15

3, 960/7, 180

1.37

3.39 × 10-21

[5]

C13orf31-CCDC122

3, 960/7, 180

1.68

3.72 × 10-54

[5]

M. tuberculosis

Tuberculosis

-

3, 632/7, 501

1.19

6.8 × 10-9

[63]

HIV

Viral set pointa

HLA-B

486

9.6%

9.36 × 10-12

[6]

Viral set pointa

HLA-C

486

6.5%

3.77 × 10-9

[6]

HBV

Chronic infection

HLA-DP

2, 086/4, 301

1.75

6.34 × 10-39

[64,65]


aAnalyzed as a quantitative trait.

Khor and Hibberd Genome Biology 2011 12:229   doi:10.1186/gb-2011-12-10-229