Table 1

Known rhomboid protease substrates and functions across evolution

Rhomboid

Organism

Substrate

Function

References


Rho-1

Drosophila

Spitz, Keren

EGFR signaling (embryo, most developing tissues, adult)

[8-16,89]

Rho-2/Stet

Drosophila

Gurken,?

EGFR signaling in oocyte, germline

[89,90]

Rho-3/Ru

Drosophila

Spitz, Keren

EGFR signaling in embryo, eye disc

[12,89,91]

Rho-4

Drosophila

Spitz, Keren?

EGFR signaling?

[89]

Rho-7

Drosophila

DmOpa1-like DmPINK1

Mitochondrial fusion, mitophagy

[30,55]

CeROM1

C. elegans

LIN-3L

Amplifying EGFR signaling (vulva)

[47]

AarA

P. stuartii

TatA

Activating twin-arginine translocon, quorum sensing

[20,17,61,62,66]

GlpG

E. coli

?

?

[17-20,34-36,77,78,83-85,88]

HiGlpG

H. influenzae

?

?

[37,81]

YqgP

Bacillus subtilis

?

?

[17,18,20]

PA3086

Pseudomonas aeruginosa

?

?

[17,18,20]

AqRho

Aquifex aeolicus

?

?

[17,20]

Pcp1

Saccharomyces cerevisiae

Mgm1, Ccp1

Mitochondrial membrane fusion, pre-sequence removal

[28,52-54]

PARL

Homo sapiens Mus musculus

PINK1, others

Downregulating mitophagy, crista remodeling, anti-apoptosis

[28,29,56-60]

AtRBL2

Arabidopsis thaliana

?

?

[23]

RHBDL2

H. sapiens

TM, EphrinB1,2,3, EGF

Blood clotting? Cell migration? Cancer?

[24,48,87]

PfROM4

P. falciparum

EBA175, TRAP, other adhesins

Invasion

[26,69]

PfROM1

Plasmodium sp.

AMA1?

Invasion? Growth

[26,69,70]

TgROM1

Toxoplasma gondii

?

Growth

[25,40,68,75]

TgROM2

T. gondii

?

?

[25,40,68]

TgROM3

T. gondii

?

?

[25,68]

TgROM4

Toxoplasma gondii

AMA1, MIC2, MIC6

Invasion

[25,68,71,72]

TgROM5

Toxoplasma gondii

AMA1, MIC2, MIC6

Invasion

[25,26]

EhROM1

Entamoeba histolytica

Lectins

Phagocytosis, immune evasion

[73,74]


Only those rhomboid proteases whose proteolytic activity has been detected are included in the table. A question mark '?' denotes unknown function. EGFR, epidermal growth factor receptor.

Urban and Dickey Genome Biology 2011 12:231   doi:10.1186/gb-2011-12-10-231