Additional file 13.

Figure S4 - membrane transporter topological distribution. The number of proteins exhibiting a specific topological type - that is, of a putative number of TMSs - is plotted versus the number of predicted proteins of that topology, showing that proteins with one, two or three putative TMSs are substantially less numerous than those with four or six putative TMSs. Proteins with 9 or 10 predicted TMSs are present in much lower numbers, but there are increased numbers with 11 and 12 TMSs. Larger proteins are present in relatively small numbers. In general, transport proteins often have 6 or 12 TMSs, although programs that predict topology are often in error by 1 or 2 TMSs [127].

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Coyne et al. Genome Biology 2011 12:R100   doi:10.1186/gb-2011-12-10-r100