Research
Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer
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* Corresponding author: Edwin Cuppen e.cuppen@hubrecht.eu
1 Department of Medical Genetics, University Medical Center Utrecht, Universiteitsweg 100, Utrecht, 3584 CG, The Netherlands
2 Department of Medical Oncology, University Medical Center Utrecht, Universiteitsweg 100, Utrecht, 3584 CG, The Netherlands
3 Hubrecht Institute KNAW and University Medical Center Utrecht, Uppsalalaan 8, Utrecht, 3584 CT, The Netherlands
Genome Biology 2011, 12:R103 doi:10.1186/gb-2011-12-10-r103
Published: 19 October 2011Additional files
Additional file 1:
A flow-diagram of the procedure for detecting tumor-specific rearrangements.
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Additional file 2:
Mean insert sizes of mate-pair libraries.
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Additional file 3:
Table with SOLiD sequencing statistics of mate-pair libraries from tumor samples and healthy tissues.
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Additional file 4:
Table with all tumor-specific structural rearrangements identified by mate-pair sequencing in the four patients.
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Additional file 5:
Size distribution of tumor-specific deletions in four patients.
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Additional file 6:
Three examples of clusters of rearrangements in colorectal tumor genomes.
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Additional file 7:
Copy number changes coinciding with breakpoints of rearrangement clusters.
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Additional file 8:
Log R ratios and B allele frequencies for chromosomes affected by chromothripsis.
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Additional file 9:
PCR gel of genomic rearrangements within clusters on chromosomes 17 and 21 and chromosomes 3 and 6.
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Additional file 10:
Table indicating the presence of complex rearrangement clusters in primary and metastatic tumors.
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Additional file 11:
Sequence characteristics of tumor-specific fusion points.
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Additional file 12:
Hotspots of rearrangements in PARK2 and MACROD2.
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