Cancer-related genes affected by rearrangements breakpoints. (a) Disruption of EXO1 and FH (fumarate hydratase) by rearrangement breakpoints in a metastasis-specific cluster on chromosome 1 in patient 3. (b) Disruption of MYCBP2 by a rearrangement breakpoint in a cluster on chromosome 13 in patient 1. Genes from the Cancer Genome Census are also depicted for this cluster. (c) Disruption of SORBS2 by metastasis-specific deletions in patients 2 and 4. (d) Disruption of CSMD1 by a metastasis-specific deletion in patient 2.
Kloosterman et al. Genome Biology 2011 12:R103 doi:10.1186/gb-2011-12-10-r103