Open Access Method

Allele-specific copy number analysis of tumor samples with aneuploidy and tumor heterogeneity

Markus Rasmussen1, Magnus Sundström2, Hanna Göransson Kultima1, Johan Botling2, Patrick Micke2, Helgi Birgisson3, Bengt Glimelius45 and Anders Isaksson1*

Author Affiliations

1 Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, SE-751 85 Uppsala, Sweden

2 Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden

3 Department of Surgical Sciences, Uppsala University, Akademiska sjukhuset, SE-751 85 Uppsala, Sweden

4 Department of Radiology, Oncology and Radiation Sciences, Uppsala University Akademiska sjukhuset, SE-751 85 Uppsala Sweden

5 Department of Oncology and Pathology, Karolinska Institutet, SE-17177 Stockholm, Sweden

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Genome Biology 2011, 12:R108  doi:10.1186/gb-2011-12-10-r108

Published: 24 October 2011

Additional files

Additional file 1:

Dilution series summary. This file illustrates the sensitivity of TAPS using short-segment scatter plots of lung cancer cell line H1395, for several different tumor cell concentrations.

Format: PDF Size: 1.3MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Lung cancer cell line summaries. This file contains TAPS scatter plots illustrating the copy number analysis result of the seven lung cancer cell lines, and matching SKY karyotypes for comparison.

Format: PDF Size: 2.3MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data