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Wrangling for microRNAs provokes much crosstalk

Ana C Marques*, Jennifer Tan and Chris P Ponting*

Author Affiliations

MRC Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford OX1 3PT, UK

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Genome Biology 2011, 12:132 doi:10.1186/gb-2011-12-11-132

Published: 21 November 2011

Abstract

Levels of transcripts sharing microRNA response elements are co-regulated. These RNA-RNA interactions imply that combinations of microRNAs modulate cell-specific transcript networks.

Keywords:
MicroRNAs; competing endogenous RNAs; ceRNAs; PTEN; PTENP1; transcript networks; microRNA sponges; microRNA decoys; competitive endogenous RNAs