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BRD4 jump-starts transcription after mitotic silencing

Philipp Voigt and Danny Reinberg*

Author Affiliations

Howard Hughes Medical Institute, New York University School of Medicine, Department of Biochemistry, 522 First Avenue, New York, NY 10016, USA

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Genome Biology 2011, 12:133  doi:10.1186/gb-2011-12-11-133

Published: 29 November 2011

Abstract

The chromatin adapter BRD4 may be crucial for transmitting epigenetic information by acting as a histone acetylation-dependent gene bookmark and accelerating post-mitotic transcriptional reactivation.