Chromatin modifications substantially improve TF target gene predictions. (a) ROC curves show improved TF target gene predictions using histone modifications. (b, c) Performance of prediction models for individual TFs, with PSSMs from Beer and Tavazoie  (b) and from Harbison et al.  (c). TFs are sorted by prediction performance using histone modifications and PSSMs (red bars).
Cheng et al. Genome Biology 2011 12:R111 doi:10.1186/gb-2011-12-11-r111