Condition specificity of the chromatin model for TF target prediction. (a, b) ROC curves showing the performance of two chromatin models in predicting target genes of HSF1 (a) and the MSN2/4 complex (b). The model (model B) using histone modifications in the H2O2 condition is better at predicting target genes in the H2O2 condition (blue curve) than in YPD medium (model A; red curve), which indicates condition specificity of chromatin modifications and TF target genes.
Cheng et al. Genome Biology 2011 12:R111 doi:10.1186/gb-2011-12-11-r111