Target histone modification profiles and target-non-target differential modification profiles of TFs. (a) Target histone modification profiles comprising different normalized histone modification signals (columns) of TFs (rows). A target histone modification profile is the averaged histone modification signals of the TF's targets. TFs are clustered into histone-sensitive (blue bar) and -insensitive TFs (orange bar) using their target histone modification profiles. Histone-sensitive TFs have stronger histone modification signals. (b) Target-non-target differential modification profiles of TFs showing the discriminating power (t-statistic) of histone modifications to TF targets and non-targets. TFs are ordered the same as in (a). Histone-sensitive and -insensitive TFs have distinct differential modification profiles, indicating preferential histone modifications of TFs targets. (c) Correlation network of histone modifications in terms of TF differential modification profiles. Histone modification pairs with a correlation coefficient larger than 0.5 (red edges) or smaller than -0.5 (green edges) are connected. The network shows a high level of redundancy of histone modifications in differential modification profiles.
Cheng et al. Genome Biology 2011 12:R111 doi:10.1186/gb-2011-12-11-r111