Distinctions between histone-sensitive and -insensitive TFs. (a) Target genes of histone-sensitive TFs are better predicted using intergenic or upstream histone modifications than are those of histone-insensitive TFs. (b) Histone-sensitive TFs have a smaller number of target genes in the regulatory network than histone-insensitive TFs. (c) Histone-sensitive TFs have a larger number of interaction partners in the protein-protein interaction (PPI) network. (d) Higher mRNA expression levels of histone-sensitive TFs.
Cheng et al. Genome Biology 2011 12:R111 doi:10.1186/gb-2011-12-11-r111