Additional file 1.

Receiver operating characteristic (ROC) curve depicting the sensitivity and specificity at various IMR90 GRO-seq read density cutoffs for gene activity. This figure shows that a cutoff of 5 reads/kb/mapability achieves the best combination of sensitivity and specificity, according to the maximal accuracy metric.

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Melgar et al. Genome Biology 2011 12:R113   doi:10.1186/gb-2011-12-11-r113