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Open Access Research

Whole genome sequencing of penicillin-resistant Streptococcus pneumoniae reveals mutations in penicillin-binding proteins and in a putative iron permease

Fereshteh Fani, Philippe Leprohon, Danielle Légaré and Marc Ouellette*

Author Affiliations

Centre de recherche en Infectiologie du Centre de recherche du CHUL and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, 2705 Boul. Laurier, Québec, Canada

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Genome Biology 2011, 12:R115  doi:10.1186/gb-2011-12-11-r115

Published: 22 November 2011

Additional files

Additional file 1:

Circular maps of the genome of R6M1 and R6M2.

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Additional file 2:

Chronological appearance of PBP mutations according to the levels of penicillin resistance in R6M2.

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Open Data

Additional file 3:

PBP1a-targeting Janus cassette.

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Open Data

Additional file 4:

Oligonucleotides used in this study.

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Additional file 5:

Plasmids used in this study.

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Open Data