Table 3

Genes mutated in at least two S.pneumoniae penicillin resistant mutants

S. pneumoniae strains

Locus name

R6M1

R6M2

1974M1

1974M2


PBP1a

G544R

W411*

E248*

E158*

PBP2x

R384G,V518I, Q552E

Q281P, A369V, R384G, R426C, V518I

F388L, Q552E, V573L, V587L, G601V

A507V, P535L, Q552E

PBP2b

D415E, G665D

A395V, G435S, T451A

G435S, T451A

T431D, T451A, L492F, Q633E

Spr1178

Q28*

Q28*

Q28*

Q28*

Spr1254

G167S

T205I

WT

WT

Spr1888

T728I

Q326*

WT

WT


Mutations are shown as amino acid changes with their corresponding position in the protein. Asterisks indicate nonsense mutations. Mutations that are common in at least two strains are in bold.

Fani et al. Genome Biology 2011 12:R115   doi:10.1186/gb-2011-12-11-r115

Open Data