Table 3 |
||||
|
Genes mutated in at least two S.pneumoniae penicillin resistant mutants |
||||
|
S. pneumoniae strains |
||||
|
Locus name |
R6M1 |
R6M2 |
1974M1 |
1974M2 |
|
|
||||
|
PBP1a |
G544R |
W411* |
E248* |
E158* |
|
PBP2x |
R384G,V518I, Q552E |
Q281P, A369V, R384G, R426C, V518I |
F388L, Q552E, V573L, V587L, G601V |
A507V, P535L, Q552E |
|
PBP2b |
D415E, G665D |
A395V, G435S, T451A |
G435S, T451A |
T431D, T451A, L492F, Q633E |
|
Spr1178 |
Q28* |
Q28* |
Q28* |
Q28* |
|
Spr1254 |
G167S |
T205I |
WT |
WT |
|
Spr1888 |
T728I |
Q326* |
WT |
WT |
|
|
||||
|
Mutations are shown as amino acid changes with their corresponding position in the protein. Asterisks indicate nonsense mutations. Mutations that are common in at least two strains are in bold. |
||||
|
Fani et al. Genome Biology 2011 12:R115 doi:10.1186/gb-2011-12-11-r115 |
||||
