Contrasting patterns of HSF distribution in Alu and non-Alu sequences in upstream and genic regions of heat-shock responsive transcripts. In upstream regions, the non-Alu region had significantly higher HSF site density (P-value 2.05 × 10-24 and 1.8 × 10-20 for up-regulated and down-regulated transcripts, respectively). In genic regions, Alu regions have significantly higher HSF sites than non-Alu regions for both up-regulated (P-value 8.97 × 10-13) and down-regulated (P-value 2.58 × 10-3) transcripts.
Pandey et al. Genome Biology 2011 12:R117 doi:10.1186/gb-2011-12-11-r117