Schematic for exon array antisense signals observed in heat shock down-regulated genes. Exon array probe co-ordinates for antisense signals are within 5-kb of HSF sites in antisense-oriented Alus. This led us to hypothesize that such Alus harboring high score (≥8.7) HSF sites can initiate antisense transcripts, leading to gene down-regulation through either transcriptional interference or the sense-antisense-mediated RNA interference pathway.
Pandey et al. Genome Biology 2011 12:R117 doi:10.1186/gb-2011-12-11-r117