Genome Biology
Tools
Share this article

Email updates

Keep up to date with the latest news and content from Genome Biology and BioMed Central.

Highly Accessed Research highlight

Making enhancers from spare parts of the genome

David Fredman1, Xianjun Dong2 and Boris Lenhard34*

Author Affiliations

1 Department of Molecular Evolution and Development, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria

2 Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA

3 Institute of Clinical Sciences, Imperial College London and MRC Clinical Sciences Centre, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK

4 Department of Informatics, University of Bergen, PO Box 7803, N-5020 Bergen, Norway

For all author emails, please log on.

Genome Biology 2011, 12:138 doi:10.1186/gb-2011-12-12-138

Published: 29 December 2011

Abstract

New studies show that novel long-range enhancers of developmental genes can emerge by exaptation of protein-coding sequences with no previous regulatory function.

Keywords:
Comparative genomics; developmental regulation; enhancers; genomic regulatory blocks; whole-genome duplication