Making enhancers from spare parts of the genome
1 Department of Molecular Evolution and Development, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
2 Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA
3 Institute of Clinical Sciences, Imperial College London and MRC Clinical Sciences Centre, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
4 Department of Informatics, University of Bergen, PO Box 7803, N-5020 Bergen, Norway
Genome Biology 2011, 12:138 doi:10.1186/gb-2011-12-12-138Published: 29 December 2011
New studies show that novel long-range enhancers of developmental genes can emerge by exaptation of protein-coding sequences with no previous regulatory function.