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The relationship between proteome size, structural disorder and organism complexity

Eva Schad, Peter Tompa and Hedi Hegyi*

Author Affiliations

Institute of Enzymology, Research Center For Natural Sciences, Hungarian Academy of Sciences, Karolina Ășt 29. Budapest, 1113 Hungary

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Genome Biology 2011, 12:R120  doi:10.1186/gb-2011-12-12-r120

Published: 19 December 2011

Additional files

Additional file 1:

Correlation between gene number and complexity in 53 eukaryotic organisms. Protein-coding gene numbers in all eukaryotes in the study excluding plants (red diamonds) and all plants (green triangles).

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Additional file 2:

Total mean proteome information content values for the six phylogenetic groups of the 76 species we used in this study. Total mean proteome information content (PIC; measured as total number of amino acids contained in the main isoforms for each organism) values for the six phylogenetic groups of the 76 species we used in this study. After excluding plants we carried out a one-way analysis of variance among the remaining five groups, assuming Gaussian distribution for proteome sizes and used Bonferroni's multiple comparison test to check the significance of pairwise differences among the five phylogenetic clades.

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Additional file 3:

Prokaryotic and eukaryotic species used in our analysis, their reduced proteome size and their biological complexity. This table also contains data related to disorder, binary protein-protein interactions, protein binding sites located in disordered regions of proteins and alternative splicing.

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Additional file 4:

Data related to disorder of proteins including SCOP domains in different prokaryotes and eukaryotes.

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Additional file 5:

Disorder, protein-protein interactions and binding of proteins expressed in different human tissues. Disorder, protein-protein interactions and binding of proteins expressed in different human tissues. (a) Median disorder of proteins versus median number of interacting partners in STRING. (b)Ttotal number of predicted binding sites versus total number of protein-protein interactions.

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Open Data