Disorder, protein-protein interactions and binding of proteins expressed in different human tissues. (a) Median disorder and median number of binding proteins, both as a function of complexity. Tissue complexity is measured as the number of cell types each human tissue has. Percentage disorder values of the proteins were predicted by IUPred. PPIs were taken from STRING, and only those pairs were counted where both partners were specifically annotated as expressed in that tissue by Swissprot. (b) Total number of binding sites as predicted by ANCHOR and total number of PPIs recorded by STRING in various human tissues as a function of tissue complexity. The fitted curves are linear but appear curved because of the log scale of the y-axis. (c) Median disorder in the main isoforms and the alternative complement as a function of the fraction of alternatively spliced (AS) tissue-specific proteins in Swissprot.
Schad et al. Genome Biology 2011 12:R120 doi:10.1186/gb-2011-12-12-r120