Research
Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila
- † Equal contributors
1 Department of Biology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
2 Department of Pathology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA
3 Department of Biology, Tufts University, 165 Packard Avenue, Medford, MA 02155, USA
4 Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA
Genome Biology 2011, 12:R121 doi:10.1186/gb-2011-12-12-r121
Published: 19 December 2011Additional files
Additional file 1:
Methods used to calculate spontaneous mutation frequency and analyze mutations.
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Additional file 2:
Information about the numbers of colonies obtained in the mutation frequency experiments.
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Additional file 3:
Information about the genome rearrangements isolated in this study.
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Additional file 4:
Set of tables showing data related to tumor frequency in wild-type and mutant backgrounds and statistical analysis for tumor frequency in different genetic backgrounds.
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Additional file 5:
Lifespan analysis for lig4 blm double mutant flies.
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