Open Access Research

Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila

Ana Maria Garcia1, Robert N Salomon2, Alice Witsell3, Justine Liepkalns3, R Brent Calder4, Moonsook Lee4, Martha Lundell1*, Jan Vijg4* and Mitch McVey3*

Author Affiliations

1 Department of Biology, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA

2 Department of Pathology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA

3 Department of Biology, Tufts University, 165 Packard Avenue, Medford, MA 02155, USA

4 Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx, NY 10461, USA

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Genome Biology 2011, 12:R121  doi:10.1186/gb-2011-12-12-r121

Published: 19 December 2011

Additional files

Additional file 1:

Methods used to calculate spontaneous mutation frequency and analyze mutations.

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Additional file 2:

Information about the numbers of colonies obtained in the mutation frequency experiments.

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Additional file 3:

Information about the genome rearrangements isolated in this study.

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Additional file 4:

Set of tables showing data related to tumor frequency in wild-type and mutant backgrounds and statistical analysis for tumor frequency in different genetic backgrounds.

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Additional file 5:

Lifespan analysis for lig4 blm double mutant flies.

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